On the Risk of Alzheimer’s Disease in Survivors of Myocardial Infarction: A Mendelian Randomization Study
Yibeltal Arega Ashebir, Yian Zhang, Yongzhao Shao · 2025
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Description
Surviving a heart attack leaves people at risk for later dementia, but whether the attack itself raises Alzheimer's risk was untested. Yibeltal Ashebir, Yian Zhang, and Yongzhao Shao tested the link with genetic tools in this 2025 study. Their method, Mendelian randomization, uses gene variants as natural experiments. Data came from large genome studies of both diseases.
Sixty-two independent gene markers carried the analysis. Several sensitivity tests checked for bias and uneven effects. Alzheimer's disease has no cure and no proven prevention, so any causal handle matters. Heart attack survivors are a large, growing group in aging populations. A causal verdict would argue for brain monitoring after cardiac events.
Catalog record
| CREATOR | Yibeltal Arega Ashebir, Yian Zhang, Yongzhao Shao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |