Transcriptomic Analysis in Alzheimer’s Disease Brain During Systemic Infection
Giulia Pegoraro, Rebecca G Smith, Lachlan Ford MacBean, Adam Smith, Delphine Boche, Ehsan Pishva, Katie Lunnon · 2025
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Description
Giulia Pegoraro and six co-authors study how the Alzheimer's brain responds at the gene level when the body fights a systemic infection. Their 2025 paper notes that infections raise the risk of dementia and speed decline in patients, and many patients die with an infection present. The team read gene activity in post-mortem frontal cortex samples from 204 donors, split by disease and by whether a respiratory infection was present at death.
Over a thousand genes differed across the groups. The changed genes clustered in microglia, the brain's immune cells, and the top pathways all concerned immune response. A network analysis found one gene module tied to both disease and infection, rich in genes from two other brain cell types also involved in immunity. The authors frame the work as groundwork, with plans to add further molecular layers from the same donors.
Catalog record
| CREATOR | Giulia Pegoraro, Rebecca G Smith, Lachlan Ford MacBean, Adam Smith, Delphine Boche, Ehsan Pishva, Katie Lunnon |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |