Enrichment of somatic cancer driver mutations in Alzheimer’s disease microglia and its association with neuroinflammation
August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J Travaglini, Mariano I Gabitto, Rebecca D Hodge, Eitan S Kaplan, Ed S Lein, Philip L De Jager, D · 2025
Read Enrichment of somatic cancer driver mutations in Alzheimer’s disease microglia and its association with neuroinflammation by August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J Travaglini, Mariano I Gabitto, Rebecca D Hodge, Eitan S Kaplan, Ed S Lein, Philip L De Jager, D (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710610.txt.
Description
August Yue Huang and co-authors found cancer-linked mutations enriched in the brain's immune cells in Alzheimer's disease in a 2025 study. The cells, microglia, accumulate small somatic mutations as people age. Some of those mutations are the same drivers seen in blood cancers, an overlap no one expected to matter in the brain.
The team sequenced microglia from Alzheimer's brains and found driver mutations at higher rates than in controls. They link the mutated cells to neuroinflammation, the chronic immune activation that harms neurons. The finding suggests rogue, expanding microglia clones may fuel part of Alzheimer's inflammation. It also opens a drug angle, since cancer drugs already target some of these pathways.
Catalog record
| CREATOR | August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J Travaglini, Mariano I Gabitto, Rebecca D Hodge, Eitan S Kaplan, Ed S Lein, Philip L De Jager, D |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |