Efficacy of brexpiprazole on agitation in patients with dementia due to Alzheimer’s disease exhibiting behaviors most bothersome to caregivers: post hoc pooled analysis of two randomized controlled trials
Malaak Brubaker, David Wang, Sanjeda R Chumki, Pedro Such, Zhen Zhang, Anton M Palma · 2025
Read Efficacy of brexpiprazole on agitation in patients with dementia due to Alzheimer’s disease exhibiting behaviors most bothersome to caregivers: post hoc pooled analysis of two randomized controlled trials by Malaak Brubaker, David Wang, Sanjeda R Chumki, Pedro Such, Zhen Zhang, Anton M Palma (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710602.txt.
Description
Malaak Brubaker and co-authors present a 2025 study of a drug for unrest in people with dementia due to Alzheimer disease. Caregivers had named the acts that trouble them most, such as cursing, hitting, pacing, and asking for help again and again. The authors asked if the drug eased unrest in patients who showed those acts often.
They pooled data from two trials that lasted twelve weeks and used a fixed dose. In all, 610 patients took part, and scores came from a standard unrest scale. By week twelve, patients on the drug improved more than those on placebo in each group. Gains were seen from week eight in most groups.
Catalog record
| CREATOR | Malaak Brubaker, David Wang, Sanjeda R Chumki, Pedro Such, Zhen Zhang, Anton M Palma |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |