Longitudinal Neuropsychiatric Symptom Trajectories in Frontotemporal Dementia: From Presymptomatic to Symptomatic Conversion
Hyunwoo Lee, Imogene M Scott, Atri Chatterjee, Ian R MacKenzie, Maria I Lapid, Edward D Huey, Maria Carmela Tartaglia, Kejal Kantarci, Katherine P Rankin, Howard J Rosen, Brad F Boeve, Adam L Boxer, Ging‐Yuek Robin Hsiung, the ALLFTD Consortium · 2025
Read Longitudinal Neuropsychiatric Symptom Trajectories in Frontotemporal Dementia: From Presymptomatic to Symptomatic Conversion by Hyunwoo Lee, Imogene M Scott, Atri Chatterjee, Ian R MacKenzie, Maria I Lapid, Edward D Huey, Maria Carmela Tartaglia, Kejal Kantarci, Katherine P Rankin, Howard J Rosen, Brad F Boeve, Adam L Boxer, Ging‐Yuek Robin Hsiung, the ALLFTD Consortium (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710598.txt.
Description
Hyunwoo Lee and co-authors track mental and behavioral symptoms in families prone to frontotemporal dementia, in a 2025 study. The disease often starts with shifts in mood and conduct, years before clear illness. Three gene types drive most family cases, and each may shape symptoms in its own way. The team followed symptom paths as carriers moved from no symptoms to full disease.
Data came from 1,662 people in a long-running North American study, including carriers of all three gene types. Before symptoms, carriers and non-carriers looked much alike. Near the turn to illness, two gene groups showed sharper rises in symptoms, mainly in psychosis and overactivity. Later on, the pace of change converged across groups. The authors suggest care plans should heed gene type near the onset window.
Catalog record
| CREATOR | Hyunwoo Lee, Imogene M Scott, Atri Chatterjee, Ian R MacKenzie, Maria I Lapid, Edward D Huey, Maria Carmela Tartaglia, Kejal Kantarci, Katherine P Rankin, Howard J Rosen, Brad F Boeve, Adam L Boxer, Ging‐Yuek Robin Hsiung, the ALLFTD Consortium |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |