Sex differences in microvascular and Alzheimer’s disease‐related pathology in the medial temporal lobe: a quantitative neuropathological study
Francesco Bax, Marteen L van den Berg, Jan Oltmer, Corinne A Auger, Alexandra N Melloni, Theresa Connors, Alberto Serrano‐Pozo, Matt P Frosch, Steven M Greenberg, Bradley T T Hyman, Susanne J van Veluw, Valentina Perosa · 2025
Read Sex differences in microvascular and Alzheimer’s disease‐related pathology in the medial temporal lobe: a quantitative neuropathological study by Francesco Bax, Marteen L van den Berg, Jan Oltmer, Corinne A Auger, Alexandra N Melloni, Theresa Connors, Alberto Serrano‐Pozo, Matt P Frosch, Steven M Greenberg, Bradley T T Hyman, Susanne J van Veluw, Valentina Perosa (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710595.txt.
Description
Francesco Bax and co-authors compare sex patterns in small vessel and Alzheimer damage in a 2025 brain study. Tissue came from one hundred fifty-seven autopsy cases at one research center. Learning models measured vessel amyloid, tangles, and a third protein mark across memory regions. Vessel wall thickening was graded by eye and stain.
Women showed worse wall thickening yet lower vessel amyloid loads. Women also carried fewer plaques but denser tangles than men. A risk gene variant sharpened the tangle gap in women. No joint effect linked sex and vessel disease to Alzheimer marks. The split patterns suggest sex shapes each damage type through its own route.
Catalog record
| CREATOR | Francesco Bax, Marteen L van den Berg, Jan Oltmer, Corinne A Auger, Alexandra N Melloni, Theresa Connors, Alberto Serrano‐Pozo, Matt P Frosch, Steven M Greenberg, Bradley T T Hyman, Susanne J van Veluw, Valentina Perosa |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |