Relationship between cortical diffusivity and neuropathological substrates in Alzheimer’s disease
Justine Debatisse, Fangda Leng, Paul Edison · 2025
Read Relationship between cortical diffusivity and neuropathological substrates in Alzheimer’s disease by Justine Debatisse, Fangda Leng, Paul Edison (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710576.txt.
Description
Justine Debatisse, Fangda Leng, and Paul Edison examine a brain scan measure that may flag early Alzheimer's damage before tissue visibly shrinks. The measure, cortical mean diffusivity, tracks how freely water moves in grey matter; freer movement hints that the tiny barriers inside tissue are breaking down. The team combined several scan types for ninety participants grouped by amyloid status and diagnosis.
Diffusivity ran higher in amyloid-positive patients with mild impairment or Alzheimer's than in cognitively normal peers, across wide cortical areas and memory regions. It also tracked cortical thickness only in people without amyloid buildup. The authors argue the measure captures early microstructural injury that unfolds alongside amyloid deposition, before gross shrinkage takes over. That timing could make it useful for early detection research.
Catalog record
| CREATOR | Justine Debatisse, Fangda Leng, Paul Edison |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |