Arteriolosclerosis and LATE‐NC: two common and inter‐related contributors to Alzheimer’s‐type dementia
Peter T Nelson, Yuriko Katsumata · 2025
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Description
Peter Nelson and Yuriko Katsumata revisit two common brain findings that together shape dementia in old age, in a 2025 study. One is the thickening of tiny brain artery walls, seen in most brains past eighty. The other is a protein buildup pattern in the brain's memory areas, tied to a disease process called LATE. The team retested their link using a large national autopsy data set.
The sample held 2,558 people who died past sixty, with artery change graded from none to severe. The link between artery thickening and the protein pattern was strong and held after age and other factors were accounted for. It also held in a subset of people who died after 2014. More than a quarter of the group showed the protein change in the hippocampus. The authors cast small-vessel damage as part of the LATE condition itself.
Catalog record
| CREATOR | Peter T Nelson, Yuriko Katsumata |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |