Isolation of single neuronal nuclei by phospho‐tau accumulation in Alzheimer’s disease brain
Bowen Jin, Samuel Naik, Samantha L Kirkham, Xuyu Qian, Zinan Zhou, Derek Oakley, Matt P Frosch, Bradley T T Hyman, August Yue Huang, Michael B Miller · 2025
Read Isolation of single neuronal nuclei by phospho‐tau accumulation in Alzheimer’s disease brain by Bowen Jin, Samuel Naik, Samantha L Kirkham, Xuyu Qian, Zinan Zhou, Derek Oakley, Matt P Frosch, Bradley T T Hyman, August Yue Huang, Michael B Miller (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710559.txt.
Description
Bowen Jin and co-authors sort brain cell nuclei by tau build-up in Alzheimer's disease in this 2025 paper. The disease features clumps of amyloid and a changed form of tau protein. Only some neurons carry heavy tau damage, even in hard-hit brain areas.
Why tau strikes some neurons and spares others is not well understood. The team built a sorting method that separates nuclei with the altered tau. Fluorescence tags mark the damaged nuclei so machines can pull them apart. Single-nucleus study of each group can then reveal what sets them apart. The approach may expose early steps of the disease. It could also suggest targets that protect the neurons most at risk.
Catalog record
| CREATOR | Bowen Jin, Samuel Naik, Samantha L Kirkham, Xuyu Qian, Zinan Zhou, Derek Oakley, Matt P Frosch, Bradley T T Hyman, August Yue Huang, Michael B Miller |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |