Harbingers of Disease: Decoding Shared Multi‐Omic Changes in Human and Mouse Models of Alzheimer’s Disease
Vivek Swarup, Samuel Morabito, Emily Miyoshi, Elizabeth Head, Kim N Green · 2025
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Description
Mouse models of Alzheimer's disease do not always match the human illness, which slows the hunt for cures. Vivek Swarup and co-authors compared gene changes in human and mouse brains for a 2025 study. They used gene reads from single cell cores and from mapped tissue spots. Human samples came from the front of the brain after death, and mouse samples came from a common disease strain.
The team grouped cells in both species and lined the groups up across species. Shared changes stood out in genes that respond to amyloid, the sticky protein that builds up in the disease. Genes in microglia, the brain's immune cells, also shifted in both. Stain images of amyloid were used to link gene shifts to plaque load. Shared signals are the most promising leads for new drugs.
Catalog record
| CREATOR | Vivek Swarup, Samuel Morabito, Emily Miyoshi, Elizabeth Head, Kim N Green |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |