Investigating the microvascular dysfunction in the Frontotemporal Dementia using a progranulin‐deficient mice model
Supriya Chakraborty, Sofia Franciosa, Oliver Bracko · 2025
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Description
Supriya Chakraborty, Sofia Franciosa, and Oliver Bracko report a 2025 study on small blood vessels in frontotemporal dementia. This dementia is the second most common kind, yet its vessel side is little studied. Mice that lack the protein progranulin, a model of the disease, show stalled capillaries and weak blood flow in the brain.
The team checked whether the blood-brain barrier leaks in these mice. They stained tissue for the seal proteins that line vessel walls and for signs of leaked blood proteins. Older mice without the protein had fewer vessels, and seal protein levels shifted, which may explain the stalls.
Catalog record
| CREATOR | Supriya Chakraborty, Sofia Franciosa, Oliver Bracko |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |