Alzheimer’s Disease: Because Amyloid‐β Cannot Differentiate Between Bacteria and Neurons
Matthew P Neal, Autumn Meek, Donald F Weaver · 2025
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Description
Matthew P Neal, Autumn Meek, and Donald F Weaver build a 2025 model of Alzheimer's disease around a protein that fights germs. The protein, amyloid-beta, builds up in the sick brain, yet its first role in the body is to attack bacteria. The puzzle is why a defense protein would harm nerve cells.
The authors ran computer, cell, and animal studies on the protein's effects. They found that bacterial walls and nerve cell walls share near-identical surface patterns of charge and water affinity. A weapon aimed at germ walls can thus hit nerve cells by mistake. In their model, events like infection, injury, or poor blood flow call the protein out, and it attacks the brain's own cells. The model joins germ defense, swelling, and cell harm into one story.
Catalog record
| CREATOR | Matthew P Neal, Autumn Meek, Donald F Weaver |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |