Microtubule‐Associated Protein Tau (MAPT) in non‐transgenic and transgenic P301S mouse lenses
Juliet A Moncaster, Olga Minaeva, Lee E Goldstein · 2025
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Description
Tau, the protein that tangles in Alzheimer's brains, also turns up in the eye's lens, and whether it scars the lens was unsettled. Juliet Moncaster and two co-authors check in 2025 the lenses of ordinary mice and of mice carrying a human tau mutation, across most of their lifespan. Both sorts were bred and examined under matched conditions.
Every lens carried tau, and the mutant lenses showed an extra heavier band of it on protein blots. Yet no cataract appeared in either group at any age. The authors conclude the mutation changes tau's processing without clouding the lens. Set beside their earlier work, the result points to amyloid, not tau, as the lens's main troublemaker in this disease.
Catalog record
| CREATOR | Juliet A Moncaster, Olga Minaeva, Lee E Goldstein |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |