APOE4 Alters Tau Propagation in Regions Associated with Early Alzheimer’s Disease in a Humanized Mouse Model of Tau Spread
Hirra A Arain, Juan F Idiarte, Tsering D Lama, Helen Y Figueroa, Jia Guo, Karen E Duff, Tal Nuriel · 2025
Read APOE4 Alters Tau Propagation in Regions Associated with Early Alzheimer’s Disease in a Humanized Mouse Model of Tau Spread by Hirra A Arain, Juan F Idiarte, Tsering D Lama, Helen Y Figueroa, Jia Guo, Karen E Duff, Tal Nuriel (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710443.txt.
Description
Hirra Arain and co-authors ask whether the APOE4 gene variant changes how tau protein spreads through the brain, in a 2025 paper. Carrying APOE4 is the strongest genetic risk for the common form of Alzheimer's disease. Research long tied it to amyloid plaques, but its grip on the second hallmark, tau tangles, was unclear.
The team built a humanized mouse whose misfolded human tau starts in the entorhinal cortex, the region where tau trouble begins in patients. Crossing it with mice carrying different human APOE versions let them watch spread across the brain up to old age. Their measurements trace how APOE4 reshapes tau's path through regions tied to early disease.
Catalog record
| CREATOR | Hirra A Arain, Juan F Idiarte, Tsering D Lama, Helen Y Figueroa, Jia Guo, Karen E Duff, Tal Nuriel |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |