The moderating effects of sex and amyloid status on the associations between early tau burden and memory
Kitty K Lui, Xinran Wang, Jordan Stiver, Xin Wang, Erin E Sundermann, Tobey J Betthauser, Erin M Jonaitis, Rebecca E Langhough, Sterling C Johnson, Sarah Banks · 2025
Read The moderating effects of sex and amyloid status on the associations between early tau burden and memory by Kitty K Lui, Xinran Wang, Jordan Stiver, Xin Wang, Erin E Sundermann, Tobey J Betthauser, Erin M Jonaitis, Rebecca E Langhough, Sterling C Johnson, Sarah Banks (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710439.txt.
Description
Lui and co-authors examine how sex and amyloid status change the link between early tau buildup and memory in older adults at risk for Alzheimer's disease. Women tend to gather more tau early on, yet they often outscore men on verbal memory tests, which can mask decline. The study drew 196 mostly unimpaired volunteers from a Wisconsin prevention registry. Brain scans measured tau in the earliest affected regions and amyloid across the brain, and memory was tested in verbal and spatial forms.
In women with amyloid, more early tau went with worse scores on spatial learning, spatial recall, and verbal recall. Men with amyloid showed no such links. Among amyloid-free men, tau did track with worse spatial recall, a pattern absent in amyloid-free women. The authors argue that early tau harms memory sooner in women once amyloid is present. They call for longer studies in more diverse groups.
Catalog record
| CREATOR | Kitty K Lui, Xinran Wang, Jordan Stiver, Xin Wang, Erin E Sundermann, Tobey J Betthauser, Erin M Jonaitis, Rebecca E Langhough, Sterling C Johnson, Sarah Banks |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |