Deciphering spatial microglial diversity in the brain of Alzheimer’s disease patients
Paula Sanchez‐Molina, Dillon Brownell, Aditya Pratapa, Nadezhda Nikulina, Bassem Ben Cheikh, Jasmine Singh, Alina Bogachuk, Aude Chiot, Gregory Chin, Katie Emberley, Andrea Crotti, Randall Woltjer, Fabian Svara, Oliver Braubach, Bahareh Ajami · 2025
Read Deciphering spatial microglial diversity in the brain of Alzheimer’s disease patients by Paula Sanchez‐Molina, Dillon Brownell, Aditya Pratapa, Nadezhda Nikulina, Bassem Ben Cheikh, Jasmine Singh, Alina Bogachuk, Aude Chiot, Gregory Chin, Katie Emberley, Andrea Crotti, Randall Woltjer, Fabian Svara, Oliver Braubach, Bahareh Ajami (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710437.txt.
Description
Paula Sanchez-Molina and co-authors map microglial diversity in Alzheimer disease brains in a 2025 study. Microglia are the brain own immune cells, and single cell work shows they vary greatly. Capturing protein and location data together in human tissue is hard, yet needed to link cell types to disease features.
The team used a multiplex imaging method with thirty two barcoded antibodies on the same tissue section. The panel covered neurons, support cells, vessels, and disease markers. New segmentation and analysis tools handled complex cell shapes. Results map brain architecture and show how microglial types relate to pathological features.
Catalog record
| CREATOR | Paula Sanchez‐Molina, Dillon Brownell, Aditya Pratapa, Nadezhda Nikulina, Bassem Ben Cheikh, Jasmine Singh, Alina Bogachuk, Aude Chiot, Gregory Chin, Katie Emberley, Andrea Crotti, Randall Woltjer, Fabian Svara, Oliver Braubach, Bahareh Ajami |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |