Differential effects of Apoe Christchurch (R136S) mutation on amyloid plaque and tau pathology in transgenic mouse models
Kristine M Tran, Shimako Kawauchi, Nellie Kwang, Cassandra Mar, Donna Chao, Celia Da Cunha, Andrea J Tenner, Frank M LaFerla, Grant R MacGregor, Kim N. Green · 2025
Read Differential effects of Apoe Christchurch (R136S) mutation on amyloid plaque and tau pathology in transgenic mouse models by Kristine M Tran, Shimako Kawauchi, Nellie Kwang, Cassandra Mar, Donna Chao, Celia Da Cunha, Andrea J Tenner, Frank M LaFerla, Grant R MacGregor, Kim N. Green (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710434.txt.
Description
Kristine Tran and co-authors test a rare protective gene variant in mouse models of Alzheimer's disease in a 2025 study. A woman carrying a strong Alzheimer's gene stayed sharp for decades, and she also carried this APOE variant. In her brain, tau damage was low even though amyloid plaques were not. The team asked whether the variant splits the two hallmarks in mice too.
Using gene editing, they placed the variant into mice bred for plaque disease and for tau disease. Brain slices were stained for immune cells, and spatial gene and protein tools mapped cell responses. Blood markers of nerve damage were also tracked. Early results in the plaque model show lower plaque load at twelve months, a finding the full paper develops.
Catalog record
| CREATOR | Kristine M Tran, Shimako Kawauchi, Nellie Kwang, Cassandra Mar, Donna Chao, Celia Da Cunha, Andrea J Tenner, Frank M LaFerla, Grant R MacGregor, Kim N. Green |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |