Older adults at‐risk for type 2 diabetes exhibit decreased performance on spatial and working memory tasks using classic and novel cognitive testing
Olivia R Ghosh‐Swaby, Jennifer Hanna Al‐Shaikh, Daniel Palmer, Ali R. Khan, Jane Thornton, Timothy J Bussey, Lisa M Saksida, Teresa Liu‐Ambrose, Lindsay Nagamatsu · 2025
Read Older adults at‐risk for type 2 diabetes exhibit decreased performance on spatial and working memory tasks using classic and novel cognitive testing by Olivia R Ghosh‐Swaby, Jennifer Hanna Al‐Shaikh, Daniel Palmer, Ali R. Khan, Jane Thornton, Timothy J Bussey, Lisa M Saksida, Teresa Liu‐Ambrose, Lindsay Nagamatsu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710431.txt.
Description
Olivia Ghosh-Swaby and co-authors test the thinking skills of older adults who stand at diabetes' doorstep, looking for early cracks. Type 2 diabetes and aging both raise dementia risk, and people merely at risk, through weight or blood sugar, may already show cognitive slippage. Detecting it early could change what doctors prescribe first.
Sixty-five at-risk older adults, mostly women, took both classic paper tests and touchscreen tasks translated from rodent research, which probe spatial and working memory with unusual sensitivity. Performance sagged on both families of tests, and the deficit tracked with metabolic risk markers. Sensitive testing may catch the mind's decline while lifestyle intervention can still bend the curve.
Catalog record
| CREATOR | Olivia R Ghosh‐Swaby, Jennifer Hanna Al‐Shaikh, Daniel Palmer, Ali R. Khan, Jane Thornton, Timothy J Bussey, Lisa M Saksida, Teresa Liu‐Ambrose, Lindsay Nagamatsu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |