Hyperhomocysteinemia and hypertension exacerbate cerebrovascular dysfunction and Alzheimer’s Disease pathology in the Tg2576 mouse model of amyloidosis
Ashley M Carey, Silvia Fossati · 2025
Read Hyperhomocysteinemia and hypertension exacerbate cerebrovascular dysfunction and Alzheimer’s Disease pathology in the Tg2576 mouse model of amyloidosis by Ashley M Carey, Silvia Fossati (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710423.txt.
Description
Ashley Carey and Silvia Fossati present a 2025 mouse study of two heart and vessel risks in Alzheimer type disease. High levels of a blood compound and high blood pressure can each harm brain vessels. The team asked if mice exposed to both would show worse vessel harm and disease signs.
Disease model mice and normal mice got a diet, a drug in water, or both from midlife. Brains were checked months later for cell death, barrier leaks, new vessel growth, and amyloid load. Mice with the risks showed more vessel cell death and worse barrier and growth harm. Amyloid signs also trended higher. The authors say the mix adds harm through shared paths.
Catalog record
| CREATOR | Ashley M Carey, Silvia Fossati |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |