Plasma biomarkers of vascular injury and cerebrovascular reactivity in APOE4 carriers
Arunima Kapoor, Shubir Dutt, Amy Nguyen, Aimée Gaubert, John Paul M Alitin, Isabel Sible, Anisa J Marshall, Fatemah Shenasa, Allison C Engstrom, Xingfeng Shao, David Bradford, Kathleen E. Rodgers, Danny JJ Wang, Daniel A. Nation · 2025
Read Plasma biomarkers of vascular injury and cerebrovascular reactivity in APOE4 carriers by Arunima Kapoor, Shubir Dutt, Amy Nguyen, Aimée Gaubert, John Paul M Alitin, Isabel Sible, Anisa J Marshall, Fatemah Shenasa, Allison C Engstrom, Xingfeng Shao, David Bradford, Kathleen E. Rodgers, Danny JJ Wang, Daniel A. Nation (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710418.txt.
Description
Blood markers of vessel injury may explain weak blood flow control in the brain for people carrying the APOE4 gene, in a 2025 study by Arunima Kapoor and co-authors. APOE4 raises the risk of dementia, and carriers show early problems with how brain vessels react. The team tested whether inflammation and vessel lining damage sit behind those problems.
Sixty-five older adults without dementia gave blood and had brain scans. The scans measured how vessels reacted when carbon dioxide levels shifted up and down. Blood was checked for four markers tied to inflammation and vessel lining stress. Early results link the vessels' reaction to one breathing condition with marker levels, after accounting for age and sex.
Catalog record
| CREATOR | Arunima Kapoor, Shubir Dutt, Amy Nguyen, Aimée Gaubert, John Paul M Alitin, Isabel Sible, Anisa J Marshall, Fatemah Shenasa, Allison C Engstrom, Xingfeng Shao, David Bradford, Kathleen E. Rodgers, Danny JJ Wang, Daniel A. Nation |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |