Accumulation of Novel Amyloidosis‐associated proteins in the Progression of Alzheimer’s disease
Wangchen Tsering, Kiara Lolo, Jennifer L Phillips, Todd Golde, Stefan Prokop · 2025
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Description
Wangchen Tsering and co-authors describe a 2025 study of proteins that gather with amyloid plaques in Alzheimer disease. Not all plaques harm the brain in the same way; loose plaques look mild, while dense core plaques sit amid swollen fibers. The team asked which partner proteins track with each type.
They stained donor brain tissue from cases at low, mid, and high disease stages. They mapped plaque types by area and stage and checked which proteins sat with them. Patterns of plaque type and partner proteins differed by area and stage. Local immune cell activity also matched those patterns. The authors say this map can guide treatment aimed at the harmful plaque form.
Catalog record
| CREATOR | Wangchen Tsering, Kiara Lolo, Jennifer L Phillips, Todd Golde, Stefan Prokop |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |