Systems genetic dissection of Alzheimer’s disease brain gene expression networks
Pinghan Zhao, Omar El Fadel, Anh Le, Carl Grant Mangleburg, Timothy Wu, Justin Dhindsa, Bismark K Amoh, Aditi Sai Marella, Yarong Li, Nicholas T Seyfried, Allan I Levey, Zhandong Liu, Ismael Al‐Ramahi, Juan Botas, Joshua M Shulman · 2025
Read Systems genetic dissection of Alzheimer’s disease brain gene expression networks by Pinghan Zhao, Omar El Fadel, Anh Le, Carl Grant Mangleburg, Timothy Wu, Justin Dhindsa, Bismark K Amoh, Aditi Sai Marella, Yarong Li, Nicholas T Seyfried, Allan I Levey, Zhandong Liu, Ismael Al‐Ramahi, Juan Botas, Joshua M Shulman (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710402.txt.
Description
Genes in the Alzheimer's brain switch on and off in coordinated groups, but which groups drive the disease and which merely react to it stays hard to prove. Pinghan Zhao and co-authors attack that sorting problem in a 2025 study with a cross-species trick. Gene groups found in human brain data are tested one by one in fruit flies carrying the disease's hallmark proteins.
Flies let the team flip hundreds of genes and watch whether brain decay sped or slowed. One group that rises in disease, rich in immune genes, proved to be a driver that worsens decay. A second group, tied to synapses and falling in disease, acted as a brake. The authors offer the sorted map as a guide to which networks drug hunters should push or protect.
Catalog record
| CREATOR | Pinghan Zhao, Omar El Fadel, Anh Le, Carl Grant Mangleburg, Timothy Wu, Justin Dhindsa, Bismark K Amoh, Aditi Sai Marella, Yarong Li, Nicholas T Seyfried, Allan I Levey, Zhandong Liu, Ismael Al‐Ramahi, Juan Botas, Joshua M Shulman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |