Study of the irisin hormone on metabolism and mitochondrial dynamics in experimental models of Alzheimer’s disease
Ariene Soares Fonseca, Mariana Gomes Chauvet, Sergio T Ferreira, Mychael V Lourenco · 2025
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Description
Ariene Soares Fonseca, Mariana Gomes Chauvet, Sergio Ferreira, and Mychael Lourenco published a 2025 study on irisin, a hormone released with exercise, in models of Alzheimer disease. Alzheimer brains use glucose poorly and resist insulin, which starves cells and adds stress. Irisin is known to spur energy burning in fat and to protect neurons in Alzheimer models.
The team asked whether irisin fixes the metabolic faults caused by amyloid beta oligomers, the toxic clusters in Alzheimer disease. They tested brain slices and mice exposed to those clusters. Irisin brought only subtle changes to the metabolic profile. It did not clearly change the proteins that govern how mitochondria split and fuse. The authors conclude that irisin's protective effect likely works through other routes.
Catalog record
| CREATOR | Ariene Soares Fonseca, Mariana Gomes Chauvet, Sergio T Ferreira, Mychael V Lourenco |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |