Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons
Claudia Espinosa‐Garcia, Upasna Srivastava, Prateek Kumar, Brendan R Tobin, Hailian Xiao, Lihong Cheng, Pritha Bagchi, Duc M Duong, Nicholas T Seyfried, Victor Faundez, Levi B Wood, Srikant Rangaraju · 2025
Read Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons by Claudia Espinosa‐Garcia, Upasna Srivastava, Prateek Kumar, Brendan R Tobin, Hailian Xiao, Lihong Cheng, Pritha Bagchi, Duc M Duong, Nicholas T Seyfried, Victor Faundez, Levi B Wood, Srikant Rangaraju (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710382.txt.
Description
Claudia Espinosa-Garcia and co-authors describe a 2025 study of how brain swelling stress changes nerve cells by cell part. Swelling plays a key role in Alzheimer disease, yet cell parts such as the body, contacts, and power units may not respond alike. The team used a tagging method to pull out proteins from one nerve cell type.
Mice got a stress drug for four days, then brain samples were split into whole cell and contact rich parts. Protein tests showed near distinct change lists for each part, with just two shared proteins. Whole cells raised clean-up work, while contact parts raised power unit work. One signal path fell only in the contact part. The authors say part level views reveal hidden effects.
Catalog record
| CREATOR | Claudia Espinosa‐Garcia, Upasna Srivastava, Prateek Kumar, Brendan R Tobin, Hailian Xiao, Lihong Cheng, Pritha Bagchi, Duc M Duong, Nicholas T Seyfried, Victor Faundez, Levi B Wood, Srikant Rangaraju |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |