BIN1 regulation of brain region‐specific tau pathogenesis and propagation
Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Om Patel, Mitchell Hansen, Lisa Collier, Gopal Thinakaran · 2025
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Description
Moorthi Ponnusamy and co-authors study in 2025 how the BIN1 gene shapes tau spread in Alzheimer-like mouse brains. BIN1 is the second strongest genetic risk factor for late-onset Alzheimer's disease. Brain BIN1 levels fall in patients, and the protein binds tau in lab tests.
Mice bred to lack BIN1 in forebrain nerve cells grow tau tangles in a set pattern. Seeded tau spreads less after the loss in key brain regions. Memory areas like the hippocampus show lighter tau load and less cell loss. The region-specific shield hints that BIN1 loss slows disease in some zones.
Catalog record
| CREATOR | Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Om Patel, Mitchell Hansen, Lisa Collier, Gopal Thinakaran |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |