A harmonized memory composite score for cross‐cohort Alzheimer’s disease and related dementia research: development and validation
Mark E. Sanderson‐Cimino, Alden L. Gross, Leslie S. Gaynor, Emily W. Paolillo, Kaitlin B. Casaletto, Ankita Chatterjee, Marilyn S. Albert, Liana G. Apostolova, Brooke Boersema, Adam L. Boxer, Brad F. Boeve, Lindsay R. Clark, Renaud La Joie, Ani Eloyan, Sarah Tomaszewski Farias, Mitzi M. Gonzales, Du · 2025
Read A harmonized memory composite score for cross‐cohort Alzheimer’s disease and related dementia research: development and validation by Mark E. Sanderson‐Cimino, Alden L. Gross, Leslie S. Gaynor, Emily W. Paolillo, Kaitlin B. Casaletto, Ankita Chatterjee, Marilyn S. Albert, Liana G. Apostolova, Brooke Boersema, Adam L. Boxer, Brad F. Boeve, Lindsay R. Clark, Renaud La Joie, Ani Eloyan, Sarah Tomaszewski Farias, Mitzi M. Gonzales, Du (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710346.txt.
Description
Mark Sanderson-Cimino and a large team of co-authors built a shared memory score for dementia research across many study groups. Centers in the United States use a common test battery, but each adds its own list-learning task. That makes memory scores hard to compare across sites. The 2025 study used data from 5,287 people at eighteen centers and four consortia to fuse the tasks into one score.
A factor method tied the varied list tasks to the common tests as anchors. Which list task a site used barely moved the score. Higher scores tracked younger age, more schooling, and milder disease. The score also matched brain scan measures of the hippocampus. The team offers it as a common yardstick for trials.
Catalog record
| CREATOR | Mark E. Sanderson‐Cimino, Alden L. Gross, Leslie S. Gaynor, Emily W. Paolillo, Kaitlin B. Casaletto, Ankita Chatterjee, Marilyn S. Albert, Liana G. Apostolova, Brooke Boersema, Adam L. Boxer, Brad F. Boeve, Lindsay R. Clark, Renaud La Joie, Ani Eloyan, Sarah Tomaszewski Farias, Mitzi M. Gonzales, Du |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |