Neuroinflammation and synapse loss determines the cognitive fate in Alzheimer Disease
Sunny Kumar, Ibai Diez, Ana Claudia Amaral, Cinthya Aguero, Charles Zachary Klein, Margaret Scapellato, Riddhimaa Sinha, Teresa Gomez‐Isla · 2025
Read Neuroinflammation and synapse loss determines the cognitive fate in Alzheimer Disease by Sunny Kumar, Ibai Diez, Ana Claudia Amaral, Cinthya Aguero, Charles Zachary Klein, Margaret Scapellato, Riddhimaa Sinha, Teresa Gomez‐Isla (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710343.txt.
Description
Sunny Kumar and seven co-authors ask why some brains bear Alzheimer's damage yet keep clear minds. Plaques and tangles can sit in a brain with no dementia at all. Their 2025 study reads post-mortem brains from 103 people in two long aging cohorts, split by damage and by mind fate.
Demented and resilient brains held like counts of tangles, but demented ones bore more tau threads and more loose tau at the synapses. Cleaner cells loaded with waste marks ran high in demented and frail brains, not in resilient ones. Synapse loss tracked the same split. Gene reads showed resilient brains kept down genes for cell death and swelling. The team ties mind fate to tau at synapses plus swelling.
Catalog record
| CREATOR | Sunny Kumar, Ibai Diez, Ana Claudia Amaral, Cinthya Aguero, Charles Zachary Klein, Margaret Scapellato, Riddhimaa Sinha, Teresa Gomez‐Isla |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |