Effects of BDNF and COMT variants on cognitive decline in Early‐Onset Alzheimer’s Disease
Dustin B Hammers, Tatiana M Foroud, Hee Jin Kim, Jane Musema, Jeffrey L Dage, Ani Eloyan, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova, Kelly N Nudelman, LEADS Consortium · 2025
Read Effects of BDNF and COMT variants on cognitive decline in Early‐Onset Alzheimer’s Disease by Dustin B Hammers, Tatiana M Foroud, Hee Jin Kim, Jane Musema, Jeffrey L Dage, Ani Eloyan, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova, Kelly N Nudelman, LEADS Consortium (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710335.txt.
Description
Dustin Hammers and co-authors test whether two common gene variants speed decline in early-onset Alzheimer's in a 2025 paper. The early form strikes between ages 40 and 64 and makes up only about five percent of cases. Variants in the BDNF and COMT genes have been tied to thinking changes in other settings.
The team followed 88 amyloid-positive patients for twelve months. Carrying the BDNF variant predicted steeper drops in memory and executive function scores. The analysis adjusted for age, schooling, sex, and ancestry. Effects on the age when symptoms began were also checked. The work helps explain why patients with the same diagnosis decline at different rates.
Catalog record
| CREATOR | Dustin B Hammers, Tatiana M Foroud, Hee Jin Kim, Jane Musema, Jeffrey L Dage, Ani Eloyan, Maria C Carrillo, Bradford C Dickerson, Gil D Rabinovici, Liana G Apostolova, Kelly N Nudelman, LEADS Consortium |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |