Circulating microRNAs related to cognitive performance in the general population
Konstantinos Melas, Valentina Talevi, Dennis Manfred Krüger, Tonatiuh Pena, N Ahmad Aziz, André Fischer, Monique MB Breteler · 2025
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Description
Melas and co-authors searched for blood microRNAs tied to thinking ability in the general population. These small RNA molecules have been linked to dementia, but their place in everyday cognition is unclear. Using data from 2,869 adults in a German population study, the team grouped these molecules into clusters that move together. They compared the clusters with test scores for memory, executive function, and overall cognition, plus brain imaging.
One cluster was significantly tied to weaker executive function, and another, at suggestive strength, to weaker verbal memory. Several single microRNAs also tracked with cognition, and some with thinner cortex in frontal and temporal regions. The target genes of these molecules cluster in pathways for brain development and synapse building. The authors say the findings could feed early detection of cognitive decline.
Catalog record
| CREATOR | Konstantinos Melas, Valentina Talevi, Dennis Manfred Krüger, Tonatiuh Pena, N Ahmad Aziz, André Fischer, Monique MB Breteler |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |