Investigating microglial modulation of endothelial inflammation through IL1RAP
Elizabeth S Fisher, Kate Tubbesing, Katherine Stevens, Steven Lotz, Taylor Bertucci, Sally Temple · 2025
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Description
Elizabeth Fisher and co-authors study how microglia shape vessel inflammation through a receptor partner called IL1RAP, in a research paper from 2025. Most Alzheimer patients show vessel damage that comes before memory decline. A gene variant in IL1RAP tracks with higher disease rates and faster amyloid build-up, which hints the pathway may modify the disease.
The team grew microglia and vessel lining cells from human stem cells carrying two APOE forms. Cells were challenged with inflammatory signals. Gene activity, cytokine release, and barrier strength were measured. The setup lets the team test whether microglial signals through IL1RAP weaken the blood-brain barrier. Results may point to a new drug target.
Catalog record
| CREATOR | Elizabeth S Fisher, Kate Tubbesing, Katherine Stevens, Steven Lotz, Taylor Bertucci, Sally Temple |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |