Differential Roles of Human Tau Isoforms in the Modulation of Inflammation and Development of Neuropathology
Brian Spencer, Jennifer Ngolab, Aaron Schueler, Daniel Sung, Robert A Rissman · 2025
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Description
Brian Spencer and co-authors study in 2025 how two forms of the tau protein shape brain disease. Tau, which clumps in Alzheimer disease, comes in a three-repeat and a four-repeat form that occur in near equal shares in patients. Most mouse models carry only the four-repeat form, which skews the picture.
The team crossed two mouse lines to make animals with both forms. By three months, the double-form mice showed more tau buildup and more activated support cells in memory and cortex regions than either single-form line. Tests of learning, nesting, and activity tracked the changes. The model offers a closer match to human disease.
Catalog record
| CREATOR | Brian Spencer, Jennifer Ngolab, Aaron Schueler, Daniel Sung, Robert A Rissman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |