Persistent DNA damage response drives cGAS‐STING mediated neuroinflammation in a mouse model of tauopathy
Himanshi Singh, Jianfeng Xiao, Sazzad Khan, Asmita Das, Tayebeh Pourmotabbed, Mohammad Moshahid Khan · 2025
Read Persistent DNA damage response drives cGAS‐STING mediated neuroinflammation in a mouse model of tauopathy by Himanshi Singh, Jianfeng Xiao, Sazzad Khan, Asmita Das, Tayebeh Pourmotabbed, Mohammad Moshahid Khan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710310.txt.
Description
Himanshi Singh and co-authors linked lasting DNA damage to brain swelling and redness in a mouse model of tau disease, in a study published in 2025. Tau diseases, including Alzheimer's, involve clumps of tau protein and steady nerve cell loss. The team focused on breaks in DNA and on a cell alarm system that reacts to them.
In brain samples from patients and from mice, breaks were more common and repair proteins were lower than in healthy tissue. The alarm system, known by the short names cGAS and STING, was also more active where tau harm was present. The authors argue that unrepaired breaks may help switch on this alarm, driving the harmful swelling that follows. That chain could offer new points for treatment.
Catalog record
| CREATOR | Himanshi Singh, Jianfeng Xiao, Sazzad Khan, Asmita Das, Tayebeh Pourmotabbed, Mohammad Moshahid Khan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |