A systems‐biology approach to identify candidate genes associated with composite brain pathology scores in the Adult Changes of Thought (ACT) and the Religious Orders Study and Memory and Aging Project (ROSMAP) autopsy cohorts
Aheli Dutta, Jai Broome, Sagnik Sinha, Laura E. Gibbons, Lincoln MP Shade, Yuriko Katsumata, Kyle J Travaglini, Mariano I Gabitto, Zijie Zhao, Qiongshi Lu, Julie A. Schneider, Caitlin S Latimer, C Dirk Keene, Paul K. Crane, David W. Fardo, Shubhabrata Mukherjee · 2025
Read A systems‐biology approach to identify candidate genes associated with composite brain pathology scores in the Adult Changes of Thought (ACT) and the Religious Orders Study and Memory and Aging Project (ROSMAP) autopsy cohorts by Aheli Dutta, Jai Broome, Sagnik Sinha, Laura E. Gibbons, Lincoln MP Shade, Yuriko Katsumata, Kyle J Travaglini, Mariano I Gabitto, Zijie Zhao, Qiongshi Lu, Julie A. Schneider, Caitlin S Latimer, C Dirk Keene, Paul K. Crane, David W. Fardo, Shubhabrata Mukherjee (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710291.txt.
Description
Aheli Dutta and co-authors used a systems-biology approach in 2025 to find genes tied to combined brain pathology scores in two autopsy cohorts. Earlier work had built one harmonized score that joins many forms of postmortem brain damage across studies. The new step was to hunt the genetic loci behind that single score.
Genome scans ran separately in each cohort with standard tools, and the systems approach joined those results with other biological layers. The cohorts are long-running studies of aging and memory whose members donate their brains. Readers get candidate genes for the total burden of brain pathology, not just one lesion type. A combined score can reveal shared roots that single-diagnosis studies miss.
Catalog record
| CREATOR | Aheli Dutta, Jai Broome, Sagnik Sinha, Laura E. Gibbons, Lincoln MP Shade, Yuriko Katsumata, Kyle J Travaglini, Mariano I Gabitto, Zijie Zhao, Qiongshi Lu, Julie A. Schneider, Caitlin S Latimer, C Dirk Keene, Paul K. Crane, David W. Fardo, Shubhabrata Mukherjee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |