XBP‐1s transcriptional targets in the endoplasmic reticulum unfolded protein response ameliorate tauopathy
Brian C. Kraemer, Marina Han · 2025
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Description
Brian Kraemer and Marina Han hunt the gene team that lets a cell stress switch fight tau clumps, in a study from 2025. Tau clumps mark a set of brain ills. A switch called XBP-1s, part of the cell's unfolded protein reply, was known to curb tau harm in worms.
Gene reads on worms with the switch on gave a list of its wards. Each ward on the list proved a must: knock one out and the shield fell. One ward, a heat-shock helper in the cell's fold shop, held the lead role. Too much of it hurt; a fair dose helped. Two cell-death genes were musts too. The map shows the shield is a broad net with no spare parts, a fact drug teams must weigh.
Catalog record
| CREATOR | Brian C. Kraemer, Marina Han |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |