Hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, Ivabradine, attenuates brain mitochondrial oxidative stress without reducing cognitive impairment in Dox‐induced chemobrain
Hiranya Pintana, Nattayaporn Apaijai, Adivitch Sripusanapan, Chotrawee Piriyakunthorn, Titikorn Chunchai, Damrongsak Jinarat, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakorn · 2025
Read Hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, Ivabradine, attenuates brain mitochondrial oxidative stress without reducing cognitive impairment in Dox‐induced chemobrain by Hiranya Pintana, Nattayaporn Apaijai, Adivitch Sripusanapan, Chotrawee Piriyakunthorn, Titikorn Chunchai, Damrongsak Jinarat, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakorn (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710247.txt.
Description
Hiranya Pintana and co-authors tested a heart drug in rats with drug-linked memory harm, in a study published in 2025. The cancer drug doxorubicin can cause a foggy state often called chemobrain. The team asked whether ivabradine, a drug used for chest pain and fast heart rates, could protect the brain.
Twenty male rats were split into four groups, with some given the cancer drug and some also given the test drug for a month. The cancer drug hurt memory, brain signaling, and the energy parts of brain cells. The test drug eased oxygen stress in those cell parts but did not fix the memory loss. That split result helps show which brain harms may need a different kind of help.
Catalog record
| CREATOR | Hiranya Pintana, Nattayaporn Apaijai, Adivitch Sripusanapan, Chotrawee Piriyakunthorn, Titikorn Chunchai, Damrongsak Jinarat, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakorn |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |