Genes that escape X chromosome inactivation are associated with Alzheimer’s disease endophenotypes: findings from ROSMAP
Mabel Seto, Michelle Clifton, Gillian T Coughlan, Rory Boyle, Colin Birkenbihl, Ting‐Chen Wang, Philip L De Jager, Julie A Schneider, Reisa A Sperling, Yanling Wang, David A Bennett, Timothy J Hohman, Hyun‐Sik Yang, Logan C Dumitrescu, Rachel F Buckley · 2025
Read Genes that escape X chromosome inactivation are associated with Alzheimer’s disease endophenotypes: findings from ROSMAP by Mabel Seto, Michelle Clifton, Gillian T Coughlan, Rory Boyle, Colin Birkenbihl, Ting‐Chen Wang, Philip L De Jager, Julie A Schneider, Reisa A Sperling, Yanling Wang, David A Bennett, Timothy J Hohman, Hyun‐Sik Yang, Logan C Dumitrescu, Rachel F Buckley (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710246.txt.
Description
Mabel Seto and co-authors studied genes on the X chromosome that stay active in women, and their links to Alzheimer's disease, in a paper published in 2025. Women face the disease more often than men and tend to show more brain damage from it. Some X genes escape the normal silencing of one copy, which may help explain that gap.
Using brain gene data, plaque and tangle measures, and memory scores from a long-running study, the team checked more than two hundred such genes. Dozens linked to plaques, tangles, or memory decline, and most links were seen only in women. One gene stood out for links to both lower plaques and lower tangles. The results point to sex-linked biology that drug research has largely missed.
Catalog record
| CREATOR | Mabel Seto, Michelle Clifton, Gillian T Coughlan, Rory Boyle, Colin Birkenbihl, Ting‐Chen Wang, Philip L De Jager, Julie A Schneider, Reisa A Sperling, Yanling Wang, David A Bennett, Timothy J Hohman, Hyun‐Sik Yang, Logan C Dumitrescu, Rachel F Buckley |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |