Back to the Future! Understanding old mechanisms and discovering new insights via ADSP initiatives
William S Bush, Anthony J Griswold · 2025
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Description
William Bush and Anthony Griswold review a giant gene project in a 2025 paper on Alzheimer's disease. The project has sequenced whole genomes from huge numbers of people and paired them with computing and population methods. Its goal is to lay bare how the disease starts and varies.
The roster is set to grow past 110,000 participants. New tools join the old: long read sequencing can spot tangled structural changes that short reads miss, across many ancestries. A partner consortium will fold in layers of gene activity data. The authors frame the next phase as going back to the roots of known mechanisms with sharper tools.
Catalog record
| CREATOR | William S Bush, Anthony J Griswold |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |