Targeting Alzheimer’s disease with a Geroscience approach
Martin Darvas · 2025
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Description
Martin Darvas reports a 2025 conference abstract on a three-drug mix aimed at aging itself in Alzheimer's disease. The mix joins acarbose, rapamycin, and phenylbutyrate, each aimed at a different aging process. Old mice ate the mix in their chow, then received virus injections that seeded amyloid and tau changes in the hippocampus.
At 27 months, the seeded mice did worse than control mice on two memory tasks. They alternated less in a Y-shaped maze and froze less in a fear test. Mice on the drug mix performed better on both tasks. The results support treating aging pathways, not just single disease proteins.
Catalog record
| CREATOR | Martin Darvas |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |