Fatty Acid Amide Hydrolase Single Nucleotide Polymorphism rs324420A/C Associations with Alzheimer’s Disease
Daniel K Mori‐Fegan, Yuen Yan Wong, Shiropa Noor, Che‐Yuan Wu, Ruth A Ross, Walter Swardfager · 2025
Read Fatty Acid Amide Hydrolase Single Nucleotide Polymorphism rs324420A/C Associations with Alzheimer’s Disease by Daniel K Mori‐Fegan, Yuen Yan Wong, Shiropa Noor, Che‐Yuan Wu, Ruth A Ross, Walter Swardfager (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710220.txt.
Description
Daniel K Mori-Fegan and co-authors present a 2025 study of a gene variant that tunes the brain's own cannabis-like signalling, and its links to Alzheimer's disease. The gene makes an enzyme that breaks down a calming messenger called anandamide. One common variant weakens the enzyme, leaving more of the messenger active, and has been tied to lower trauma disorder risk but higher addiction risk.
Whether that variant also shifts Alzheimer's risk was unknown. The team set out to test the link, given the signalling system's hand in brain inflammation. A clean answer would add a genetic thread to how this internal system shapes late-life brain disease.
Catalog record
| CREATOR | Daniel K Mori‐Fegan, Yuen Yan Wong, Shiropa Noor, Che‐Yuan Wu, Ruth A Ross, Walter Swardfager |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |