SNX19 contributes to neurodegeneration by disrupting the endolysosomal system in neurons
Liang Ma, Luis Aguirre, Debroah Holstein, Vanesa Estevez, James Lechleiter, Jenny Hsieh, Sudha Seshadri · 2025
Read SNX19 contributes to neurodegeneration by disrupting the endolysosomal system in neurons by Liang Ma, Luis Aguirre, Debroah Holstein, Vanesa Estevez, James Lechleiter, Jenny Hsieh, Sudha Seshadri (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710218.txt.
Description
Liang Ma and co-authors investigate a gene called SNX19 as a new suspect in Alzheimer's disease, in a 2025 report. The gene works in the cell's recycling and cleanup system, long tied to brain degeneration, but its exact role was unclear. In postmortem human brains, the team found SNX19 concentrated in excitatory neurons, and its levels there tracked with the neuritic plaques of the disease.
To test cause, they deleted the gene in human stem cells and grew neurons and brain organoids from them. The edited neurons raised their synaptic markers, and the organoids changed shape. The authors say the work in progress positions SNX19 as a fresh factor in Alzheimer's biology worth pursuing.
Catalog record
| CREATOR | Liang Ma, Luis Aguirre, Debroah Holstein, Vanesa Estevez, James Lechleiter, Jenny Hsieh, Sudha Seshadri |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |