Macroscale structural covariance network reveals the biological mechanisms of neuropsychiatric symptoms in the Alzheimer’s continuum
Jiwei Jiang, Kun Zhao, Peiyang Zheng, Shirui Jiang, Jun Xu · 2025
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Description
Jiwei Jiang and co-authors present a 2025 conference abstract on mood and behavior symptoms across the Alzheimer's disease continuum. The team built a brain network for each patient from scan data, using a method that links regions with similar tissue patterns. Their sample held 487 patients, some with these symptoms and some without.
From 300 key network links, the team sorted patients with symptoms into three subtypes. Two subtypes showed strong but opposite patterns of network damage, faster drops in test scores, and loss of grey matter in key brain areas. The third subtype looked much like patients without symptoms. Gene tests then tied each subtype to its own set of body pathways.
Catalog record
| CREATOR | Jiwei Jiang, Kun Zhao, Peiyang Zheng, Shirui Jiang, Jun Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |