Molecular and Synaptic Signatures in Mouse Models of Late‐Onset Alzheimer’s Disease Independent of Amyloid and Tau Pathology
Adrian L Oblak · 2025
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Description
Adrian Oblak reports 2025 work on mouse models of late-onset Alzheimer's disease that lack the classic plaques and tangles. A large program breeds mice with human-like gene risk traits for the late form of the disease. Such mice should copy the human illness better than older gene-added models, which lean on rare early forms.
One model pairs two risk traits with a human form of the plaque protein, fed plain food or a high fat, high sugar diet. By 18 months, the rich-diet mice lost some nerve cells and showed more stray plaque protein and a blood sign of nerve harm. Gene and protein reads shifted in fat use and in cell links, and scans showed smaller brain areas. The mice also learned a touch task more slowly.
Catalog record
| CREATOR | Adrian L Oblak |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |