Multimodal Genetic Analysis of Brain Amyloidosis
Ting‐Chen Wang, Derek B. Archer, Muhammad Ali, Yiyang Wu, Elizabeth Mormino, Rachel F. Buckley, Annie J. Lee, Andrew J. Saykin, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Lisa L. Barnes, Badri N. Vardarajan, Richard Mayeux, Brian W. Kunkle, William S. Bush, C. Dirk Keene, Sudha Seshad · 2025
Read Multimodal Genetic Analysis of Brain Amyloidosis by Ting‐Chen Wang, Derek B. Archer, Muhammad Ali, Yiyang Wu, Elizabeth Mormino, Rachel F. Buckley, Annie J. Lee, Andrew J. Saykin, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Lisa L. Barnes, Badri N. Vardarajan, Richard Mayeux, Brian W. Kunkle, William S. Bush, C. Dirk Keene, Sudha Seshad (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710194.txt.
Description
Ting-Chen Wang and a large consortium of co-authors present a 2025 genetic study of brain amyloidosis, the plaque buildup central to Alzheimer's disease. Gene hunts using diagnosis alone are blunt; measuring amyloid directly should sharpen them, but each measurement method alone gives modest sample sizes. The team combined two genome-wide studies: one using amyloid brain scans in about seven thousand people, one using autopsy plaque ratings in about six and a half thousand.
Meta-analyzing the two sharpened the search for DNA variants that drive plaque formation. Careful cutoffs defined amyloid positivity in each cohort, matched by a statistical model for the scans. The authors argue pairing imaging and pathology endophenotypes is a practical way to enlarge genetic studies of Alzheimer's mechanisms.
Catalog record
| CREATOR | Ting‐Chen Wang, Derek B. Archer, Muhammad Ali, Yiyang Wu, Elizabeth Mormino, Rachel F. Buckley, Annie J. Lee, Andrew J. Saykin, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Lisa L. Barnes, Badri N. Vardarajan, Richard Mayeux, Brian W. Kunkle, William S. Bush, C. Dirk Keene, Sudha Seshad |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |