Using polygenic risk scores and APOE e4 to evaluate the risk for Alzheimer’s disease in European ancestry populations
Dongbing Lai, Michael Zhang, Tatiana M Foroud · 2025
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Description
Dongbing Lai, Michael Zhang, and Tatiana M Foroud report a 2025 conference abstract on judging Alzheimer's risk with gene scores. Doctors often rely on one strong risk gene form, APOE e4, but many smaller gene effects also add up. The team combined a broad gene score with APOE e4 status to sort risk more finely.
The team tested the approach in two large samples of people of European ancestry. A high gene score or an e4 copy each raised risk on its own. Having both raised risk far more, up to about fourteen times in one sample. Effects also ran larger in women than in men in one dataset.
Catalog record
| CREATOR | Dongbing Lai, Michael Zhang, Tatiana M Foroud |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |