Aberrant XIST beyond the inactivated X chromosome modulates the intracellular dysregulation in Alzheimer’s disease
Somenath Sen, Debashis Mukhopadhyay · 2025
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Description
Somenath Sen and Debashis Mukhopadhyay trace a famous RNA, XIST, acting out of place in Alzheimer's disease. XIST normally silences one X chromosome in female cells, a housekeeping role in gene balance. Their 2025 study mines gene sequencing data from the memory center of post-mortem Alzheimer's brains, human and a mouse model. XIST levels are altered in the disease, and lab cell models confirm the change. Imaging and cell fraction tests then locate where the RNA sits and how much of it has strayed.
Alzheimer's strikes women more often, and a sex-linked regulator gone rogue could be part of that story. Long non-coding RNAs are rising suspects in brain disease generally. The authors connect XIST's straying to the cell's wider dysregulation. Their chain runs from human tissue to mouse to dish. The work nominates a new player in a heavily studied disease.
Catalog record
| CREATOR | Somenath Sen, Debashis Mukhopadhyay |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |