Genome‐wide DNA methylation in early‐onset dementias brain tissue and lymphoblastoid cell lines
Aina Comas‐Albertí, Oscar Ramos‐Campoy, Laura Fort‐Aznar, David Hervás‐Marín, Sergi Borrego‐Écija, Bea Bosch, Juan Sandoval, Fermin Moreno, Guadalupe Fernandez‐Villullas, Laura Molina, Mircea Balasa, Albert Lladó, Raquel Sanchez‐Valle, Anna Antonell · 2025
Read Genome‐wide DNA methylation in early‐onset dementias brain tissue and lymphoblastoid cell lines by Aina Comas‐Albertí, Oscar Ramos‐Campoy, Laura Fort‐Aznar, David Hervás‐Marín, Sergi Borrego‐Écija, Bea Bosch, Juan Sandoval, Fermin Moreno, Guadalupe Fernandez‐Villullas, Laura Molina, Mircea Balasa, Albert Lladó, Raquel Sanchez‐Valle, Anna Antonell (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710154.txt.
Description
Aina Comas-Albertí and co-authors map DNA methylation in early-onset dementias in a 2025 study. Methylation, a chemical mark on DNA, can switch genes and may help drive brain disease. Comparing several dementia forms that start early reduces the noise of aging, and the team also tested whether cultured blood cell lines can model early disease phases.
They profiled 64 samples from prefrontal cortex and cell lines across Alzheimer disease and frontotemporal dementia, in both sporadic and gene-driven forms, with five people per group. Patients' groups showed extra methylation as the most common change. Statistical learning built methylation signatures that could aid diagnosis, and mark levels were compared with gene activity data from the same cohort.
Catalog record
| CREATOR | Aina Comas‐Albertí, Oscar Ramos‐Campoy, Laura Fort‐Aznar, David Hervás‐Marín, Sergi Borrego‐Écija, Bea Bosch, Juan Sandoval, Fermin Moreno, Guadalupe Fernandez‐Villullas, Laura Molina, Mircea Balasa, Albert Lladó, Raquel Sanchez‐Valle, Anna Antonell |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |