Aquaporin‐4: Unraveling the Link Between Reactive Astrogliosis and Neuroinflammation in Down syndrome with Alzheimer’s Disease Pathogenesis
Cherie A Stringer, Haley Miyasato, Kevin Camey, Phong Ngo, Elizabeth J Andrews, Florence Lai, Milos D Ikonomovic, Julia Kofler, Sierra Wright, Michael J Phelan, Elizabeth Head · 2025
Read Aquaporin‐4: Unraveling the Link Between Reactive Astrogliosis and Neuroinflammation in Down syndrome with Alzheimer’s Disease Pathogenesis by Cherie A Stringer, Haley Miyasato, Kevin Camey, Phong Ngo, Elizabeth J Andrews, Florence Lai, Milos D Ikonomovic, Julia Kofler, Sierra Wright, Michael J Phelan, Elizabeth Head (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710143.txt.
Description
Cherie A Stringer and co-authors share a 2025 conference abstract on a water channel protein in Down syndrome brains. People with Down syndrome build up amyloid early and often develop Alzheimer's disease. The protein, aquaporin-4, sits in support cells called astrocytes and may help clear amyloid, but it can shift out of place as amyloid grows.
The team studied post-mortem brain samples from controls and from people with Down syndrome, with and without Alzheimer's changes. In Down syndrome with Alzheimer's, the protein sat away from its normal spot and was present at higher levels. Support cells also showed shapes tied to reactive, inflamed states.
Catalog record
| CREATOR | Cherie A Stringer, Haley Miyasato, Kevin Camey, Phong Ngo, Elizabeth J Andrews, Florence Lai, Milos D Ikonomovic, Julia Kofler, Sierra Wright, Michael J Phelan, Elizabeth Head |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |