MIAMI‐AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease
Lily Wang, David Lukacsovich, Deirdre O'Shea, Hanchen Huang, Wei Zhang, Juan I Young, X. Steven Chen, Sven‐Thorsten Dietrich, Brian W. Kunkle, Eden R. Martin · 2025
Read MIAMI‐AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease by Lily Wang, David Lukacsovich, Deirdre O'Shea, Hanchen Huang, Wei Zhang, Juan I Young, X. Steven Chen, Sven‐Thorsten Dietrich, Brian W. Kunkle, Eden R. Martin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710142.txt.
Description
Lily Wang and co-authors build a knowledge base for DNA methylation in aging and Alzheimer's disease in a 2025 paper. Methylation marks on DNA shift with age and with the disease, and women carry more of the disease burden than men. Results from single studies are hard to compare. Their base, called MIAMI-AD, hand-collects summary results from ninety-seven tables across thirty-seven studies, each with at least one hundred people.
Users can search by single mark, by gene, by region, or across the whole genome. A special section covers epigenetic clocks that estimate biological age. Tools in the base let users compare patterns across studies and across sexes. A shared, curated shelf of results should speed the hunt for marks that truly track the disease.
Catalog record
| CREATOR | Lily Wang, David Lukacsovich, Deirdre O'Shea, Hanchen Huang, Wei Zhang, Juan I Young, X. Steven Chen, Sven‐Thorsten Dietrich, Brian W. Kunkle, Eden R. Martin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |