Complement receptor 1 length polymorphism impacts glial functions relevant to Alzheimer’s disease
Nikoleta Daskoulidou, Paul Morgan · 2025
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Description
Nikoleta Daskoulidou and Paul Morgan report a 2025 lab study on a gene tied to Alzheimer disease risk. Large gene scans link the complement system, part of the immune defense, to the disease. One gene in that system comes in a short and a long form, and the long form tracks with higher risk.
The team grew brain support cells and immune cells of the brain from stem cells of donors with each form. They then watched how well the cells ate targets such as amyloid fibrils and bits of nerve endings. The work probes how a risk gene may shift the cleanup work of brain cells.
Catalog record
| CREATOR | Nikoleta Daskoulidou, Paul Morgan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |