The role of immune system associated genes in patients with Alzheimer’s disease: A large case‐control study in the Chinese population
Xuewen Xiao, Bin Jiao, Rui Yao, Xinxin Liao, Jincheng Li, Beisha Tang, Lu Shen · 2025
Read The role of immune system associated genes in patients with Alzheimer’s disease: A large case‐control study in the Chinese population by Xuewen Xiao, Bin Jiao, Rui Yao, Xinxin Liao, Jincheng Li, Beisha Tang, Lu Shen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11710125.txt.
Description
Xuewen Xiao and co-authors present a 2025 conference abstract on immune genes in Alzheimer's disease in China. The immune system can help or harm the disease process, but which immune genes matter is unsettled. The team sequenced 370 immune-linked genes in 1,511 patients and 2,001 healthy controls.
One common variant in the MGMT gene showed a suggestive link with disease risk after strict correction. Rare harmful variants in two genes, RAB37 and EPCAM, also showed nominal links in gene-level tests. The team adjusted for age, sex, and APOE e4 status throughout. The findings add immune candidates for follow-up in this population.
Catalog record
| CREATOR | Xuewen Xiao, Bin Jiao, Rui Yao, Xinxin Liao, Jincheng Li, Beisha Tang, Lu Shen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |